What is the Difference Between K2 EDTA and K3 EDTA ? K2 EDTA and K3 EDTA are two types of anticoagulants used in routine hematological tests. However, their influence on the blood count remains controversial.The main difference between K2 EDTA and K3 EDTA is that K2 EDTA contains two chelated potassium ions whereas K3 EDTA contains